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KMID : 0369820070370040229
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 4 p.229 ~ p.235
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Controlled Release of Nifedipine in Multi-Layered Granule System
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Lee Soo-Young
Kim Moon-Suk
Lee Hai-Bang
Gang Gil-Seon
Youn Ju-Yong
Kim Byung-Soo
Lee Bong
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Abstract
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Multi-layered granules were prepared by a fluidized-bed coater and uniformed granules were obtained with a size range between in diameter. The granule system was composed of three layers, i.e. seed layer with sugar sphere bead and a water-swellable polymer, middle layer with a drug, solubilizer and polymer, and the top layer of porous membrane with a polymeric binder. The aim of this work is to find out the dependence of a drug dissolution rate on the amount of a water-soluble binder and a solubilizer in the granule system. The results showed that the higher amount of hydrophilic binder in the porous membrane, gave the bigger pore size and porosity and made faster dissolution rate and also the higher amount of solubilizer in drug layer enhanced the dissolution rate of drug.
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KEYWORD
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Multi-Layered granule, Nifedipine, Fluidized-bed coater, Porous membrane, Solubilizer, Binder
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